Factors @ Stark Lab

This website provides data we acquired on enhancer control by transcription factors (TFs) and cofactors. Enhancers are usually controlled by combinations of TFs. While TF binding is extensively studied using ChIP and related methods, little is yet known about the regulatory events that follow TF binding and the specific TF combinatorics required for activation and repression. We studied the requirements of transcriptional control by attaching the DNA-binding domain of GAL4 to individual TFs and cofactors. Here we provide the data we acquired for 474 TFs and 338 transcriptional cofactors (chromatin remodelers and modifiers and components of the basal transcription machinery) being targeted to 24 contexts.

As an entry point use one of the examples below, search for a specific protein at the bottom of the page, or perform an advanced search.