Factors @ Stark Lab

Gene Name	Type	Activity (log2) in S2 cells (avg/min/max)	Cluster	Data available
Gene Name	Type	Activity (log2) in S2 cells (avg/min/max)	Cluster	S2	Kc167	BG3	OSC	HeLa
Lpt (FBgn0263667)	cofactor	(5.11/-0.86/7.32)	8	◼	◼	◼	◼	◼

Factor activity

Celltype:
S2
Kc167
BG3
OSC
HeLa

Additional information

Lpt [FlyBase] | Lpt [FlyMine] | Lpt [BDGP]

H. sapiens orthologues¹

MLL3 (HGNC:13726, ENSG00000055609), MLL2 (HGNC:15840, ENSG00000272333)

Functionally similar transcription factors and cofactors

Similarity:

Euclidean distance

TF	Euclidean distance (rank)
tgo	8.752 (1)
Eip78C	10.203 (2)
CG30431	10.245 (3)
CG30020	10.437 (4)
Antp	10.470 (5)

All TFs

Cofactor	Euclidean distance (rank)
MED25	9.129 (1)
MED15	9.607 (2)
CG7154	9.960 (3)
nej	10.280 (4)
CG34376	17.521 (5)

All cofactors

Pearson correlation

TF	Pearson correlation (rank)
Rfx	0.728 (1)
tgo	0.609 (2)
CG9215	0.589 (3)
E2f	0.587 (4)
CG5196	0.574 (5)

All TFs.

Cofactor	Pearson correlation (rank)
Brd8	0.565 (1)
MBD-like	0.477 (2)
MED15	0.476 (3)
CG15356	0.463 (4)
His2Av	0.458 (5)

All cofactors.

CDS DNA Sequence²

ATGAGCACGAACGTTGTTGTGAGCATGGAGGAGAAGGCGGTGGCCGACGACCTGCCGTACTTCCCGGAGAAGTTTCCGGGCAAGGTGTGCTGTTTATGCAATCTCGGCGAGAAGAGTGCCTTGGGCCAGGGCGAGATTCTACAACTGAAGGCGCCCGCGCCCGCCGAGATCAAGGATAAATATCCGACGGATCGGCTGAGGGAGGACGGATCCAGGCTGTTATACGGGCCTAAGCAGGCCGCTTCTAGTTCGGGCGATTGTCACTACGAGCTGGACAAGATTGGACAGCCGGACGTCGTGCATCCCGCCGAATTTCTTGACGAGGGGTTCGTCTACGTGCACCGCATGTGCATCATGTGGTCGCTGCGCAAAAGTCAGATAAGCGATGCAGATGGCGCGTACTTTGCCACCCACTTCGCGGAGTTCCTGGAGCAAAAGTGCAACTTTTGTGGACGCTACGGGGCCTCCATCAACTGCAAGATGAACTGCCGCCAGGTGCACCATTGGCCGTGTGCCGCCGCTGCTGGGTGCCTTCTGATCCTCGAGAGCTTTACGGTCTTCTGCACGGAACATTTGAGCCAGGTGCCTGTGATATGCAGCGACAATAATGTGGAGTGTCTGTCCTGCTCCTCGCTGGGGGATCTGTCCAAGCTGATCATGTGTAGTACCTGCGGAGACCACTTTCATTCGACCTGCATTGGTCTGGCCAATTTGCCGGATACGCGTTCTGGGTGGAACTGCGCCCGTTGCACAAAATGCCAGATTTGCAGGCAGCAAGACTCGAACGACACCAAGTACGTTAAGTGTGAGCAATGCCAGAAGACTTACCACGCCTCCTGCTTGCGACCAGTTATCTCAGCCATCCCCAAATATGGCTGGAAGTGCAATCGCTGTCGCGTCTGTACGGATTGTGGTTCAAGAACTCCTGGCGGCGGCAGCTCCTCCCGCTGGCATAGCCACTACACAATCTGCGATTCGTGCTATCAGCAGCGGAACAAGGGCTTTTCCTGCCCGATTTGCCAGAAAGCGTACAGGGCAGCATCGCACAAGGAAATGGTCAAGTGCAGCTGGTGCAACAAATTTGTGCACAGTACGTGTGACGAAGAGGCGGATTTAACGGCCTACCACAAGAAGAAGGAGCAAAACCCAGATTACGACTACGTGTGTCCGAATTGCAAGAGTAATTCGTCGGGCCCGGGATCATCCCAACAGACAATCGACTCGATCGTGCTGTCCGCCATGGATTCGTCGTCGGAGCAACTGAGCCTCAAGGAAATCGAACTTGACCCGCTGGAGGGCAAACCCACAATGGATCCATCGAGCGATGAGCTCCACAAGCTACCCACCGGCAAGAAAAAAGTGTGCCTTACGAGTGTTCGCGGTAGAAGCGGAAAGTTCGTCCTACACCGCATGGGTGTGATGTCGCAGATCAACAAGAAACGCAGCACCCGAGGCAAGGGGCGCCAGCTTGCGCTGCCCACCATCTCGAGCGATCGCTGCCTGAGTCGCAGCATGGAAACAGATCTGACCAGCGACAAAAAGCTGCTGCTCTGCTCGGCGCGGGATAAGTTTATCCAAGCGCAAGACATCTGCGTAATGTGCGGCTCGCTGGGCATTGAGAGCGATTCCGTGATGATCACCTGCGCACAGTGCGGCCAATGCTATCATCCGTACTGCGCCGGCGTGAAGCCTTCGCGAGGCATCCTGCAGAAGGGTTGGCGATGCCTGGACTGCACAGTGTGCGAGGGATGTGGCAAGAAGAACGACGAGGCGCGCCTGCTCCTGTGCGACGAGTGCGACATTTCGTATCACATTTACTGTGTGAATCCTCCGCTGGAAACCGTGCCCACGGGCAACTGGAAGTGCTCGTTCTGTACACTGTGCCAGAAATGCGGTCGCAATCCCACCGAGAAGAGCGAGTTCGGGGACTCCAACATGCTCGAGTGCCCATCCTGCACCAGCCAATCCTCGTGTCCCGTCTGCAAAGTCTCGTACAGCAACGGCGAGATGATCATCCAGTGCGAGCACTGCGAGCTATGGGCGCACTTCCACTGCGACTCTGTCAATGCCCAGCTGACCATTGACCACTACGACAACAATGTGTACAAGTGTTTCAAGTGCCGCTGCTCGACGAGGAGCACTAACTCCCTGGCGGATGCCAAGTTTGGTAACGAGGATTCGCTGGCCATAACTCCCCAGGGCAGCAAACCATTTGTGCACATCACAGCCTCCTCCGGGCCGTCTTTCGATTCTAAGAGTGGTGCCGAGCGAAATCATCCTACCTTATCCGGCGATATGCCCGAGTCTGCTCCAGAAGCGCTCCACTGGATTGACGGAGTGTGCCTGAGCGAAAGCGGATTGGGCATGATCAAGTCATTGTCCACGGAGATCAAACGCAAGCGCAAAATGCGACAAGCCCTCGGCAATGGCAAGGATGGACAATTGGAGGCCGCCGCCGAGGAAGCGCTGGAAAAGTACAAAGACGGCATGGTCTGGGATGGGACGGAGAACGCTATTCCCGAGGGTTTCACCATCTCCATTAACGACGAGGGAGTGAACATATTACGCAAGAAGCGACAGCGCAATCTGCAGAAGCTGGGCATTGGTGGATTCTCCGTTCGCAACCGAGGTCTCAAGAAGGACAGCGAGGAGACGACGGCCGTTGACCAAATAAATTCCCTTATGACCATGGACAAAAAGAAGAAAATCATACGAAAGAAGCAGAAGAACAAGCTGATTGAAGCCTATCCCGTGTACTTGCAAGAGGCCTTCTTCGGAAAACCTCTGCTGGAAGGTGGAGAGCTTGTCATGGCCGATACAGATTCCTCTGACGAAATTGATGCGTCCATGAAGGTTTACTTCACGCGGCCCGAGGGCAAGAGTCCTGCCAACCAGGACACACTGGCGGTGAACAAGAGTCCAGCGAAGACCGTGAAGAAAGTTAAAGCTGAGTTGAAAACTGAGAACAAAACTGTTTTCATTCAGCAAATGCCCATGGGAATCCAGAACAAAAACGGAACGACGCCAGTGTCTAATGTTTTTGATCCCTTGCAAGCGGAGATTTCGAACACTGTCTTTGCTAACCGGCATCCTTTGGATGCGTTGGCTTCACCAAATGTTCCGGAACTGGACATGGCTAACTCTGTTAGTACGGTTCCATCAGCTGAAGTCATTGAAAAACCAATGCGGGAATCACCTGCGGTCCTGGTCGACAGTTTCATGGTCCCCAACCAGTTGCCACAGGAACAGAAGTTTCACAATCAGCTATATTTGGGCGGAAATACTTTGGTTAATCCCGCCCAGCAGCTTCAGTTCCGTCAGCAGGCACCACAAAATGCCAATAAGCAGAATATGCAAACTATAATGAGCCAAGTCGTTTTGCAAACCGAAAAGAGACCAGAGGAGGAGCAGAAGGTTGTGGAGCCCGTGACGGAAACCCTGAACGCTGGCACTCAAAAGACGGCGGAGAAAATGCGCAAGGATGAGGATCTTGGGCTCATGGCCACCATTTCGGCCGTGCTGTATGCCAATACTGAGCATCCCAACCTGAAGGAGTTGTTTCCGATTTGGAACGACCGCTGCAAGCAGATTCTGAAGAGGTGGCGCTCGCTGTGCAACGAGAAGAAGGCGCCGTTCTTGCAGAAGGCCAAGGACAATCGCTCAGCACTGCGGCAGAGGCGGGAACAGAACAAAATACCTATGCCACCGAAACCACAGAAGCAGGAGGAAATGGGAAGAGTGTGGAAACAACCGCCCAAGCTGAAGGAAGACCAGCCGAACATGTTTGTCACGTACAATGGAAACGCCTACGATATGGGCAACTATGTTGGTGGCTCGGCGCAGGCAGCGTCCAATAATCCCAATCCGCATCACGTGATGCCGAACGTTAACGATAATCTGGTGATTAAGGCCACGATGCAAAGGACTCAGGTGCACACGACAGCAGCCAGCACCTTGAAAATGACCACCGTGGACAATAGGCTGGAGTTGAACACGGCGGTGTACGGCACGGAACCCATTGGCGACAAGAAGCTCAGGAACCTGCTGCAGAAGAACAGCACGGAGCCGATGCTCATGGGGGCCAACTCGGACTTGTTCTTGGGCAACGATGTAATGCGGCTGGGAATGATGCAGAACACACCCATTACGCAGAACAATCCCATGCTGAGCATAAGTGGAAAATCTCAGCCATCTGAAGGCAGGTCCTTGGAGCAGGATGTGAAGTTGGGCGAGCCGCAGGAGGCAACCTCTTCCGCCGTGGAGTTGGAGAATGTCGGATTCAGCGACCTTCTGGGAGGACTCGGCGAGGGCGACGACGACGACCTACTCAAGTCGCTCACTTCCGAAATGGGAGACGACTTCAATATCCTGGAGTACGCGGACCCAGAACTGGACGTCAATGTTCTCAACTCCCTAGATTTTGATGACAATGAAAAGTGCTCTACA

CDS AA Sequence²

MSTNVVVSMEEKAVADDLPYFPEKFPGKVCCLCNLGEKSALGQGEILQLKAPAPAEIKDKYPTDRLREDGSRLLYGPKQAASSSGDCHYELDKIGQPDVVHPAEFLDEGFVYVHRMCIMWSLRKSQISDADGAYFATHFAEFLEQKCNFCGRYGASINCKMNCRQVHHWPCAAAAGCLLILESFTVFCTEHLSQVPVICSDNNVECLSCSSLGDLSKLIMCSTCGDHFHSTCIGLANLPDTRSGWNCARCTKCQICRQQDSNDTKYVKCEQCQKTYHASCLRPVISAIPKYGWKCNRCRVCTDCGSRTPGGGSSSRWHSHYTICDSCYQQRNKGFSCPICQKAYRAASHKEMVKCSWCNKFVHSTCDEEADLTAYHKKKEQNPDYDYVCPNCKSNSSGPGSSQQTIDSIVLSAMDSSSEQLSLKEIELDPLEGKPTMDPSSDELHKLPTGKKKVCLTSVRGRSGKFVLHRMGVMSQINKKRSTRGKGRQLALPTISSDRCLSRSMETDLTSDKKLLLCSARDKFIQAQDICVMCGSLGIESDSVMITCAQCGQCYHPYCAGVKPSRGILQKGWRCLDCTVCEGCGKKNDEARLLLCDECDISYHIYCVNPPLETVPTGNWKCSFCTLCQKCGRNPTEKSEFGDSNMLECPSCTSQSSCPVCKVSYSNGEMIIQCEHCELWAHFHCDSVNAQLTIDHYDNNVYKCFKCRCSTRSTNSLADAKFGNEDSLAITPQGSKPFVHITASSGPSFDSKSGAERNHPTLSGDMPESAPEALHWIDGVCLSESGLGMIKSLSTEIKRKRKMRQALGNGKDGQLEAAAEEALEKYKDGMVWDGTENAIPEGFTISINDEGVNILRKKRQRNLQKLGIGGFSVRNRGLKKDSEETTAVDQINSLMTMDKKKKIIRKKQKNKLIEAYPVYLQEAFFGKPLLEGGELVMADTDSSDEIDASMKVYFTRPEGKSPANQDTLAVNKSPAKTVKKVKAELKTENKTVFIQQMPMGIQNKNGTTPVSNVFDPLQAEISNTVFANRHPLDALASPNVPELDMANSVSTVPSAEVIEKPMRESPAVLVDSFMVPNQLPQEQKFHNQLYLGGNTLVNPAQQLQFRQQAPQNANKQNMQTIMSQVVLQTEKRPEEEQKVVEPVTETLNAGTQKTAEKMRKDEDLGLMATISAVLYANTEHPNLKELFPIWNDRCKQILKRWRSLCNEKKAPFLQKAKDNRSALRQRREQNKIPMPPKPQKQEEMGRVWKQPPKLKEDQPNMFVTYNGNAYDMGNYVGGSAQAASNNPNPHHVMPNVNDNLVIKATMQRTQVHTTAASTLKMTTVDNRLELNTAVYGTEPIGDKKLRNLLQKNSTEPMLMGANSDLFLGNDVMRLGMMQNTPITQNNPMLSISGKSQPSEGRSLEQDVKLGEPQEATSSAVELENVGFSDLLGGLGEGDDDDLLKSLTSEMGDDFNILEYADPELDVNVLNSLDFDDNEKCST

¹ H. sapiens orthologs were obtained from InParanoid8, in particular D.melanogaster-H.sapiens.orthoXML.
² Genomic sequences of the transcription factors were obtained from the dm3/BDGP Release 5 genome assembly. In the case of cofactors, the genomic sequences stand for our results obtained by deep sequencing.